NOVEL AGING BIOMARKERS IN THE HRS

Elastic Powers: the integration of biomarkers into the HRS

INTRODUCTION The title of this paper, " Elastic Powers, " appeared as the last words of Cells and Surveys, the enormously influential 2001 volume from the National Academy of Science's Committee on Population. In his closing reflections on the biosocial opportunities for surveys, Kenneth Wachter quoted from a Matthew Arnold poem that described the aging process as exhaustion from the cumulation...

The Effect of Peripheral Injection of Leptin on Biomarkers of Aging in Calorie Restricted Rats

Background and Objectives: Calorie restriction (CR) is one of the proven methods of extending lifespan and slowing aging. Leptin is a nutritionally regulated adipokine that has been proposed as a possible key signal in the adaptive responses relevant to CR. Under CR, plasma leptin levels decrease, thus it was hypothesized that leptin administration may counteract CR-induced weight loss. Therefo...

Novel Possible Biomarkers for the Cardiovascular Diseases Prognosis

Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of markers with diagnostic and prognostic value for this pathology ...

Molecular Biomarkers of Aging

Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice

We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2-9 months), middle (22-23 months) and old (33-46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44+ cells in blood, spleen and bone marrow in old PL mice th...